And appropriately enough, it's the Showtime series "Shameless."
In one episode, a man (William H. Macy) is hooking up with a woman (Joan Cusack). At first she seems demure, but when they get in private she handcuffs him to the bed frame and prepares to sodomize him with a huge dildo. He begs and pleads her not to in an obvious panic, then we hear his screams as she succeeds. It is played COMPLETELY for laughs and becomes a recurring "joke" theme throughout at least the next several episodes.
Do I even need to mention the words "public reception" and "genders reversed"? Bah. Sometimes I think the world can never be made any better.
"Don't think it hasn't been a little slice of Heaven just because it hasn't!" --Bugs Bunny