I donate to Border Angels, an organization that provides food and clothing to undocumented immigrants at the U.S.-Mexico border.
I've also been a long time donator to RAINN (Rape, Abuse and Incest National Network), even more so after experiencing firsthand how helpful the organization is.
"Don't be ashamed to need help. Like a soldier storming a wall, you have a mission to accomplish. And if you've been wounded and you need a comrade to pull you up? So what?" Meditations of Marcus Aurelius, Book 7:7